Resting heart rate (RHR) is an accessible measure that may reflect age-related cardiovascular and autonomic dysregulation relevant to cognitive ageing. However, evidence linking RHR with cognitive outcomes is inconsistent, and most studies relied on single baseline measurements that may not capture cumulative exposure. This study examined the associations of baseline and longitudinally averaged RHR with cognitive decline and d...

Frailty is a common geriatric syndrome associated with higher risks of hospitalisation and falls. The extent to which social and cognitive engagement activities (lifestyle enrichment) influence frailty is still largely unexplored. This study investigates the association between such enrichment and changes in frailty and frailty risk; 12,862 community-dwelling Australians aged ≥70 (54.4% female) enrolled in the ASPREE study wer...

Endophytic fungi symbiotically reside within plant tissues without eliciting apparent pathological responses. Positive interactions between endophytic fungi and plants help the host overcome biotic and abiotic stressors. Spodoptera frugiperda is a fall armyworm that devastates the revenue of farmers worldwide and is a major threat to food security. Here, we investigated the cytotoxicity of extracts of endophytic fungi isolated...