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Parasites play a critical yet understudied role in Arctic ecosystems, particularly within key subsistence species such as Arctic char ( Salvelinus alpinus ). As the Arctic undergoes rapid climate-driven change, establishing baseline parasite biodiversity is essential for monitoring ecological shifts and anticipating emerging health and conservation concerns. This study provides the most comprehensive assessment to date of Arct...
Humpback Whale ( Megaptera novaeangliae ) Site Fidelity, Residency, and Movement Patterns in Ireland Based on Citizen Science DataNARA Subscribed
Understanding the residency and movement patterns of large cetaceans like the humpback whale is crucial for effective conservation. In Ireland, the Irish Whale and Dolphin Group has been collecting humpback whale data since the 1990s, primarily through citizen science. This collective effort has contributed to the creation of the Irish Humpback Whale Photo‐identification Catalogue. Using this dataset, we assessed humpback whal...
Assessment of two minimally invasive methodologies for sex identification in the European eel, Anguilla anguillaNARA Subscribed
Sex is an important driver of variation in behaviour, ecology and physiology. Sex identification in the Critically Endangered European eel ( Anguilla anguilla ) currently requires fish sacrifice, or the use of morphological differences such as body length, which can be inaccurate in certain habitats and at intermediate body lengths. Non‐lethal tools for accurate sex identification in this species are therefore required. Here,...
Development and Evaluation of Foundational Cancer Science Graduate Courses in the Evolving Landscape of Cancer ResearchNARA Subscribed
Roswell Park is a free-standing Comprehensive Cancer Center in Buffalo, New York and serves as the academic home to a doctoral program in Cancer Sciences. To meet the evolving cancer research landscape, we developed and implemented a series of sequential Integrated Cancer Sciences (ICS-I, ICS-II, and ICS-III) courses that provide a strong, multi-disciplinary foundational knowledge to graduate trainees, regardless of their even...
Miniature pigs are an established preclinical model for subcutaneous (SC) drug administration; however, research on the direct translatability of this model is limited. This post hoc analysis of preclinical and clinical data assessed the translatability of performance characteristics of a high-volume auto-injector (HVAI) and SC injection site outcomes from the miniature pig model to humans. An HVAI was developed to subcutaneou...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A phase I clinical study to evaluate rapid, high-volume, subcutaneous auto-injector tolerability with recombinant human hyaluronidaseNARA Subscribed
Until recently, approved handheld auto-injectors (AIs) have been limited to volumes ≤ 2 mL. A prototype rapid high-volume AI (HVAI) that can deliver 10 mL in 30 s was developed to administer therapeutics co-formulated with a proprietary recombinant human hyaluronidase PH20 (rHuPH20). This phase I, open-label study assessed the tolerability of subcutaneous (SC) injections of 10% (100 mg/mL) immunoglobulin G (IgG) solution co-ad...
Salmonid fishes exhibit marked intra-specific variation in muscle pigmentation, primarily due to individual differences in the accumulation and assimilation of dietary carotenoids. Carotenoids are synthesized by primary producers and microorganisms, and present in the tissues of crustaceans that can serve as important prey for salmonids. Despite anadromous Arctic char ( Salvelinus alpinus ) being a key subsistence and economic...
Animal morphometrics are essential for understanding a species’ life history and its ecological interactions with the environment. This study investigates the maturity status and body condition of humpback whales ( Megaptera novaeangliae ) across understudied areas of the Northeastern Atlantic Ocean. Uncrewed Aerial Systems (UAS or drones) were used to collect photogrammetry data from humpback whales in Ireland, Norway, and Ca...