Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should be selected for testing. In this study, we compared expected costs and number of identified pathogenic variants in two scenarios: offering genetic testing to...

In this study we present data collected between August 2017 and December 2018 from submarine sediment trap M1 located in the eastern tropical North Atlantic and determine lithogenic and biogenic fluxes, and grain-size distributions of aerosol dust. An unprecedented high sampling resolution of four days in combination with satellite imagery allowed the identification of thirteen major dust events of two types within the 468-day...

A large share of the global forest restoration potential is situated in artificial ‘unstable’ mesic African savannas, which could be restored to higher carbon and biodiversity states if protected from human‐induced burning. However, uncertainty on recovery rates in protected unstable savannas impedes science‐informed forest restoration initiatives. Here, we quantify the forest restoration success of anthropogenic fire exclusio...

This study assessed whether the toxicological effects of deoxynivalenol (DON) produced by Fusarium graminearum in rainbow trout ( Oncorhynchus mykiss ) are altered by the co-exposure to a mixture of toxins produced by Fusarium verticillioides (FU mix ). This FU mix contained fusaric acid and fumonisin B 1 , B 2 and B 3 . Four diets were formulated according to a 2 × 2 factorial design: CON-CON; CON-FU mix ; DON-CON; and DON-FU...

Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options for patients with isolated synchronous colorectal cancer peritoneal metastases (CRC-PM). Therefore, the aim of this study is to analyze the outcome of the different palliative treatments for these patients. All patients diagnosed with isolated synchronous CRC-PM between 2009 and 2020 (Netherl...

Patients with peritoneal metastases (PM) of colorectal cancer have a very poor outcome. Intraperitoneal delivery of chemotherapy is the preferred route for PM treatment. The main limitation of the treatment options is the short residence time of the cytostatic, with subsequent short exposure of the cancer cells. To address this, a supramolecular hydrogel has been developed that allows both local and slow release of its encapsu...

We present a fully coupled 2DV morphodynamic model, implemented in OpenFOAM® that is capable of simulating swash-zone morphodynamics of sandy beaches. The hydrodynamics are described by the Reynolds-averaged Navier–Stokes (RANS) equations with a k−ω turbulence model and the Volume of Fluid (VoF) approach for discriminating between air and water. Sediment transport is described in terms of bedload and suspended load transport....

For peritoneal metastases (PM), there are few curative treatment options, and they are only available for a select patient group. Recently, new therapies have been developed to deliver intraperitoneal chemotherapy for a prolonged period, suitable for a larger patient group. These drug delivery systems (DDSs) seem promising in the experimental setting. Many types of DDSs have been explored in a variety of animal models, using d...

Coccolithophores are among the most important calcifying pelagic organisms. To assess how coccolithophore species with different coccolith‐carbonate mass and distinct ecological resilience to ocean warming will influence the “rain ratio” and the “biological carbon pump”, 1 yr of species‐specific coccolith‐carbonate export fluxes were quantified using sediment traps moored at four sites between NW Africa and the Caribbean (i.e....

To assess the impacts of Amazon River discharge, Saharan dust deposition, N 2 ‐fixation and mixed‐layer deepening on the biological carbon pump, sediment traps were moored from October 2012 to November 2013 at two sites in the western tropical North Atlantic (49°W,12°N/57°W,12°N). Particle exports interpreted along with satellite‐ and Argo‐float data show peak fluxes in biogenic silica (31 mg m −2 d −1 ) and organic carbon (25...

Currently, studies reporting the digestibility of carbohydrates, starch and especially non‐starch polysaccharides (NSP) in fish are scarce. Carbohydrate digestibility in the diet is largely dependent upon carbohydrate composition (starch vs. NSP). NSP are often considered to be indigestible and thus of no nutritional value. The present study reviews carbohydrates in fish feed, distinguishing between total carbohydrate, starch...

Reactive oxygen species (ROS) control forkhead box O (FOXO) transcription factor activity by influencing their nuclear translocation. However, knowledge of the ROS cellular source(s) involved herein remains scarce. Recently, we have shown p47 phox -dependent activation of ROS-producing NADPH oxidase (NOX) at the nuclear pore in H9c2 rat cardiomyoblasts in response to ischemia. This localizes NOX perfectly to affect protein nuc...