W. Mulder results 63
· Newest (Page 1/3, per page 25)
Author: W. Mulder ×Clear All Filters
Search Results
Molecular characterization of Cdh12-SCON conditional knockout mice reveals unexpected splicing changesNARA Subscribed
Functional validation of candidate genes in congenital anomalies of the kidneys and urinary tract (CAKUT) and other disorders is essential for translating genetic discoveries into clinical applications. Conditional knockout mouse models are indispensable for studying gene function in complex organ systems. The Short Conditional intrON (SCON) system accelerates the generation of such models by inserting the artificial SCON into...
Within patient horizontal gene transfer dynamics of a blaNDM−7 plasmid among four different bacterial speciesNARA Subscribed
Purpose We describe the case of a 73-year old male who was found to be a carrier of an bla NDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca , Raoultella planticola and Serratia marscescens . Resu...
Marine sterols from brown seaweeds, particularly fucosterol and its oxidized derivative saringosterol, have shown therapeutic potential for Alzheimer’s disease (AD) and cardiovascular diseases. Here, we aimed to elucidate the cellular and in vivo mechanisms underlying their beneficial effects. In human HepG2 hepatocytes and CCF-STTG1 astrocytoma cells, we assessed liver x receptor (LXRα /LXRβ) activation, sterol uptake, and ef...
CADASIL is a NOTCH3 -associated cerebral small vessel disease. A pathological ultrastructural disease hallmark is the presence of NOTCH3-protein containing deposits called granular osmiophilic material (GOM), in small arteries. How these GOM deposits develop over time and what their role is in disease progression is largely unknown. Here, we studied the progression of GOM deposits in humanized transgenic NOTCH3 Arg182Cys mice,...
Multiple hypotheses explain variation in extra‐pair paternity at different levels in a single bird familyNARA Subscribed
Extra‐pair paternity ( EPP ), where offspring are sired by a male other than the social male, varies enormously both within and among species. Trying to explain this variation has proved difficult because the majority of the interspecific variation is phylogenetically based. Ideally, variation in EPP should be investigated in closely related species, but clades with sufficient variation are rare. We present a comprehensive mul...
Climate change, phenology, and habitat degradation: drivers of gosling body condition and juvenile survival in lesser snow geeseNARA Subscribed
Nesting migratory geese are among the dominant herbivores in (sub) arctic environments, which have undergone unprecedented increases in temperatures and plant growing days over the last three decades. Within these regions, the H udson B ay L owlands are home to an overabundant breeding population of lesser snow geese that has dramatically damaged the ecosystem, with cascading effects at multiple trophic levels. In some areas t...
Imaging of angiogenesisNARA Subscribed