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Pharmaceutical Research · 2026 · Vol. 43 · Issue 6 · Springer
Objective To evaluate physiological and anatomical changes in children with liver cirrhosis supporting the development of physiologically based pharmacokinetic (PBPK) models. Methods A literature review was conducted (December 2023–May 2024) using PubMed and Google Scholar to identify studies reporting physiological and anatomical parameters in children (< 18 years) with liver cirrhosis. Parameters were analyzed in relation to...