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Updates to the RIFM Criteria Document for fragrance ingredient evaluationNARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 217 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; M.A. Guttenberg; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; F. Siddiqi; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 2-propanol, 1,1′,1′,1'-(1,2-ethanediyldinitrilo)tetrakis-, CAS Registry Number 102-60-3NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, octyl crotonate, CAS Registry Number 22874-79-9NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, propenylguaethol, CAS Registry Number 94-86-0NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, ethyl 3-hydroxybutyrate, CAS Registry Number 5405-41-4NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 3-(p-tert-butylphenyl)-2-methylpropanol, CAS Registry Number 56107-04-1NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, ethyl 3-hydroxyhexanoate, CAS Registry Number 2305-25-1NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, linoleic acid, CAS Registry Number 60-33-3NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, β-naphthyl isobutyl ether, CAS Registry Number 2173-57-1NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 1,5-dimethylhexyl acetate, CAS Registry Number 67952-57-2NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile, CAS Registry Number 68084-04-8NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, cyclohexaneethyl acetate, CAS Registry Number 21722-83-8NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, 3,5,5-trimethylcyclohexanol, CAS Registry Number 116-02-9NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, 5-methyl-2-phenyl-2-hexenal, CAS Registry Number 21834-92-4NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 4-heptanol, 2,6-dimethyl-,acetate, CAS Registry Number 10250-45-0NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, phenylacetaldehyde glyceryl acetal, CAS Registry Number 29895-73-6NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, cyclohexanemethanol, 2,4-dimethyl-, CAS Registry Number 68480-15-9NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, 2,2,6-trimethylcyclohexanone, CAS Registry Number 2408-37-9NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, cis-4-(isopropyl)cyclohexanemethanol, CAS registry number 13828-37-0NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, cyclohexanone, 2-ethyl-4,4-dimethyl-, CAS registry number 55739-89-4NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, squalene, CAS Registry Number 111-02-4NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, β-guaiene, CAS Registry Number 88-84-6NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, 3-hexene, 1,1′,''-[ethylidynestris(oxy)]tris-, (3Z, 3′Z,3"Z)-, CAS registry number 215305-10-5NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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Update to RIFM fragrance ingredient safety assessment, methyl 3-hydroxyhexanoate, CAS Registry Number 21188-58-9NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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RIFM fragrance ingredient safety assessment, 4-methyl-2-phenyl-2-pentenal, CAS Registry Number 26643-91-4NARA Subscribed
Food and Chemical Toxicology · 2026 · Vol. 216 · Pergamon
A.M. Api; A. Bartlett; D. Belsito; D. Botelho; M. Bruze; A. Bryant-Friedrich; G.A. Burton; M.A. Cancellieri; H. Chon; M. Cronin; S. Crotty; M.L. Dagli; W. Dekant; C. Deodhar; K. Farrell; A.D. Fryer; L. Jones; K. Joshi; A. Lapczynski; D.L. Laskin; M. Lavelle; I. Lee; H. Moustakas; J. Muldoon; T.M. Penning; A.H. Piersma; G. Ritacco; N. Sadekar; I. Schember; T.W. Schultz; F. Siddiqi; I.G. Sipes; G. Sullivan; Y. Thakkar
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