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Stem Cell Reviews and Reports · 2025 · Vol. 21 · Issue 7 · Springer
Primary ovarian insufficiency (POI) represents the cessation of ovarian function before age 40 due to follicular depletion or dysfunction. Affecting 1% of women, POI causes infertility and systemic health complications. Current treatments focus on symptom management rather than restoring ovarian function. Mesenchymal stem cells (MSCs) offer promising regenerative potential through paracrine activity, immunomodulation, and tiss...