Drug tolerance (DT) is a critical attribute of anti-drug antibody (ADA) assays for assessing clinical immunogenicity. We present a unique situation where a previously approved commercial product, atezolizumab, required re-assessment of the assay DT to meet an increased drug exposure demand arising from a new route of administration (subcutaneous) and align with updated health authority (HA) regulations. Rather than redevelop t...

In continental rifts, tectonic deformation, magmatic processes, and earthquakes interact dynamically reflecting the crust’s complex response to extensional stress and evolving subsurface and surface conditions. Recent seismotectonic activity in the Fentale-Dofen region of the Main Ethiopian Rift was driven by the intrusion of several dykes reaching up to ~ 50 km in length observed using satellite radar interferometry. Over 300...

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease that affects three million patients worldwide and currently without an effective cure. Zinpentraxin alfa, a recombinant human pentraxin-2 (rhPTX-2) protein, has been evaluated as a potential drug candidate for the treatment of IPF. Clinical pharmacokinetic analysis of zinpentraxin alfa has been challenging historically due to interference from...