Lung ischemia–reperfusion injury (IRI), a significant factor contributing to early mortality following lung transplantation (LTx), is driven by molecular mechanisms that are not yet fully understood. In this study, we elucidate a crucial signaling pathway initiated by extracellular histones (ex-His), which connects mitochondrial damage to inflammatory cell death. Through the use of a murine model of lung IRI and in vitro exper...

Globally, coral reefs are undergoing rapid degradation due to climate change. Microbiomes associated with coral are integral to host metabolism and play critical roles in coral resilience. Determining the changes in compositions and functions of these coral commensal microbes is essential for forecasting coral responses to environmental stress and guiding conservation. We investigated the structure and function of Symbiodiniac...