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NARA Subscribed1
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Springer Nature1
Journal
Familial Cancer1
Publication Year
20201
Wenzel M. Hackeng results 1 · Newest (Page 1/1, per page 25)
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Clear cell chondrosarcoma in Von Hippel-Lindau diseaseNARA Subscribed
Familial Cancer · 2020 · Vol. 19 · Issue 1 · Springer
Koen M. A. Dreijerink; Rachel S. van Leeuwaarde; Wenzel M. Hackeng; Rachel H. Giles; Wendy W. J. de Leng; Paul C. Jutte; Albert J. H. Suurmeijer; Bernadette P. M. van Nesselrooij; Lodewijk A. A. Brosens
A diagnosis of clear cell chondrosarcoma of the ulna was made in a patient with Von Hippel-Lindau disease (VHL). After surgery, genetic analysis of the tumor tissue showed loss of heterozygosity at the VHL gene locus. Immunohistochemical analysis confirmed loss of expression of the VHL protein in the tumor cells. In addition, abundant Cyclin D1 expression in the tumor was observed. Chondrosarcoma has been described before in a...
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