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NARA Subscribed1
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Springer Nature1
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The AAPS Journal1
Publication Year
20221
Weylon Garner results 1 · Newest (Page 1/1, per page 25)
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FOLFIRINOX Pharmacodynamic Interactions in 2D and 3D Pancreatic Cancer Cell CulturesNARA Subscribed
The AAPS Journal · 2022 · Vol. 24 · Issue 6 · Springer
Taylor J. Allen-Coyle; Jin Niu; Eva Welsch; Neil T. Conlon; Weylon Garner; Martin Clynes; Finbarr O’Sullivan; Robert M. Straubinger; Donald E. Mager; Sandra Roche
The multi-drug combination regime, FOLFIRINOX, is a standard of care chemotherapeutic therapy for pancreatic cancer patients. However, systematic evaluation of potential pharmacodynamic interactions among multi-drug therapy has not been reported previously. Here, pharmacodynamic interactions of the FOLFIRINOX agents (5-fluorouracil (5-FU), oxaliplatin (Oxa) and SN-38, the active metabolite of irinotecan) were assessed across a...
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