X. Han results 188
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Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PANS). Nonsteroidal anti-inflammatory drugs, including ibuprofen, provides relief to some neuropsychiatric symptoms, however, the therapeutic mechanisms are unclear. We describe the benefit of...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Click Chemistry-Based Quantification of Extracellular Matrix Turnover for Drug Screening and Regenerative MedicineNARA Subscribed
Purpose To develop and validate a bioorthogonal labeling approach for quantifying ECM remodeling in living cell and tissue culture systems. Methods Strain-promoted azide-alkyne (SPAAC) reactions, or copper-free click chemistry, were used to fluorescently label newly synthesized glycan and protein matrix components. ECM synthesis and degradation was quantified in cartilage explants, human mesenchymal stem cells, and SKBR3 breas...
Background While overall colorectal cancer (CRC) rates have declined in the United States (U.S.), early-onset CRC (EO-CRC), diagnosed before age 50, has increased. Rural U.S. residents face higher CRC incidence than non-rural counterparts. We aimed to examine the relationship between age at diagnosis and EO-CRC outcomes and whether rurality modify these associations. Methods We analyzed data from 835,907 patients aged 20–79 ye...
Objective This study investigated how cumulative environmental exposures influence offspring behaviour and inflammation-related molecular signatures in the brain and peripheral immune system. Methods A novel "triple-hit" mouse model was developed using C57Bl/6JAusB mice (N = 70), combining preconceptual social stress, antenatal high-fat diet, and a postnatal immune challenge (poly(I:C), 10 mg/kg). At 12 weeks, offspring underw...