Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF) protein. Using vascular endothelial cell-specific PHD2 gene knockout (PHD2 ECKO) mice, we investigated the role of endothelial PHD2 in aging-related obesity and exercise capacity. Briefly, PHD2 ECKO mice were obtained by...

Biological introductions provide a natural ecological experiment unfolding in a recent historical timeframe to elucidate how evolutionary processes (such as founder effects, genetic diversity and adaptation) shape the genomic landscape of populations postintroduction. The Asian icefish, Protosalanx chinensis , is an economically important fishery resource, deliberately introduced into dozens of provinces across China for decad...

High‐resolution precipitation distributions in mountainous areas are important for hydrological and ecological assessments, especially in regions with few weather stations. In this study, we proposed an improved model for precipitation downscaling by adding two new parameters, i.e. the maximum precipitation increment direction and the prevailing precipitation direction, which represent the impacts of elevation and the sources...