This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes, which has not been depicted by the known neurodegenerative disease. We performed physical and neurological examinations with International Rating Scales to assess signs of ataxia, Parkinsonism, and cognitive function, as well as brain magnetic resonance imaging scans with seven...

Ethylene response factors have been shown to be involved in the effects of plant developmental processes and to regulate stress tolerance. The aim of this study was to recognize the regulatory mechanisms of ethylene response factors on tobacco plant height. In this study, a gene-edited mutant (ERF10-KO) and wild type (WT) were utilized as experimental materials. Transcriptome and metabolome analyses were used to investigate th...

Miniaturized underwater profilers have the advantages of small size, low cost, and flexible deployment, which play together an important role in the persistent monitoring of a designated ocean area. Based on the demand for ocean observation, the system design, dynamic modeling, and dead reckoning algorithm of a miniaturized underwater profiler are carried out. The process of the persistent monitoring of designated area with a...