Fatty acids (FAs), especially the polyunsaturated fatty acids (PUFAs), play pivotal roles in growth and development. Fish possess a remarkable ability to synthesize PUFAs, rendering them a crucial and significant source of these essential FAs for human consumption. Despite extensive research on the metabolic processes of FAs, the primary processes underlying FA content variation and corresponding regulatory mechanisms remain l...

The infiltration of glioblastoma multiforme (GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1 (FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacety...