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Previous studies have suggested that internal oceanic modes such as the Interdecadal Pacific Oscillation (IPO) and Atlantic Multidecadal Oscillation (AMO) have significant effects on the decadal temperature variability over the Tibetan Plateau (TP). However, assessments of decadal variability are very sensitive to the length of study periods. Thus, the dominant factors regulating the decadal temperature variations over the TP...
GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairmentsNARA Subscribed
Aging is accompanied by progressive declines in metabolic and cognitive functions. Growth hormone secretagogue receptor (GHSR), a receptor for the gut hormone ghrelin, is highly expressed in neurons and plays a crucial role in metabolic regulation. We previously reported that aged global GHSR-ablated mice are lean and insulin-sensitive, and that neuronal GHSR-deleted mice ( Syn1‐cre;Ghsr f/f ) completely prevent diet‐induced o...