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Abnormal Brain Protein Abundance and Cross-tissue mRNA Expression in Amyotrophic Lateral SclerosisNARA Subscribed
Due to the limitations of the present risk genes in understanding the etiology of amyotrophic lateral sclerosis (ALS), it is necessary to find additional causative genes utilizing novel approaches. In this study, we conducted a two-stage proteome-wide association study (PWAS) using ALS genome-wide association study (GWAS) data ( N = 152,268) and two distinct human brain protein quantitative trait loci (pQTL) datasets (ROSMAP N...
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