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In vitro skin permeation of mitragynine: Optimisation of antioxidants for enhanced drug stability and formulation performanceNARA Subscribed
The opioid-like characteristics of mitragynine with biased μ-opioid receptor activation are attractive for pain and addiction therapy due to less addictive issue. Our previous work has shown the potential of delivering mitragynine through the skin but drug degradation hindered a reliable understanding of its permeation behaviour. This study aims to optimise the use of antioxidants in both the receptor medium and formulations f...
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