Nuclear factors of activated T cells (NFATs) are pivotal regulatory factors of immune responses, primarily by modulating T cell activity and regulating inflammatory cytokine gene transcription. The grass carp reovirus (GCRV) triggers a serious hemorrhagic condition, posing a significant threat to sustainable grass carp (Ctenopharyngodon idella) aquaculture. However, the precise function of NFAT in the host’s defense against GC...

Cystinuria is a rare genetic disorder characterized by defective l -cystine reabsorption from the renal proximal tubule, resulting in abnormally high concentrations of L-cystine and subsequent l -cystine crystallization and stone formation in urine. l -Cystine diamides have shown great promise as inhibitors of l -cystine crystallization. The free α-amino groups in l -cystine diamides have previously been shown to be necessary...