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Endothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and immune modulation. As a key component of the RNA-induced silencing complex, Argonaute 1 (AGO1) regulates tumor biology, yet the specific function of AGO1 within ECs in the tumor microenvironment remains undefined. Here, we investigated the effects of endothelial-specific AGO1 knockout (EC-AGO1-KO) on tumor vas...
Temporal and spatial pattern, sources, and main controlling factors of odor compounds in Qiandaohu ReservoirNARA Subscribed
The ubiquitous presence of algal-derived odors in large lakes and reservoirs constitutes a critical environmental concern. Particularly during the high-temperature summer months, localized regions of Qiandaohu Reservoir have exhibited markedly elevated concentrations of odor compounds. To investigate the intricate relationships among odor compounds, algae communities, and environmental factors in Qiandaohu Reservoir, and to fo...
Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cellsNARA Subscribed
Human myeloid leukemia cells (such as K562) could be used for the study of erythropoiesis, and mature erythroid markers and globins could be induced during leukemia cell differentiation; however, the pathways involved are different compared with those of hematopoietic stem cells (HSCs). We identified the differentially expressed genes (DEGs) of K562 cells and HSCs associated with stem cells and erythroid differentiation. Furth...