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Insignificant effects of loss of heterozygosity in HLA in the efficacy of immune checkpoint blockade treatmentNARA Subscribed
Background It is assumed that loss of heterozygosity and allelic copy loss in HLA gene is associated with poor response rates in immune checkpoint inhibitor treatment. H-owever, the accurate extents or consistency in cancer types have not been explored. Objective The goal of this study is to investigate quantitative relationship between HLA allelic copy loss and response rates to immune checkpoint inhibitors. Also, tumor micro...
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