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In the current work, we investigated the antitumor effects of a 30% ethanol extract of chili pepper leaves ( Capsicum annum; PLE), in Hep3B and Huh7 hepatocellular carcinoma (HCC) cells. PLE showed significant cytotoxicity and reduced the expression of pro-caspase 3 and pro-poly (ADP-ribose) polymerase (pro-PARP) in Hep3B and Huh7 cells. Also, it also suppressed glycolysis-related proteins, including hexokinase 2 (HK2), pyruva...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
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