Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated that miR-146b-5p plays an important role in colorectal cancer progression. However, a safe and effective strategy for delivery of an ASO to its targeted RNA remains as a major hurdle in translational advances. Human umbilical cord mesenchymal cell (hUC-MSC)–derived exosomes were used as vehicles to deli...

The deep scattering layer (DSL), a stratum of the marine diel vertical migration (DVM) organisms inhabiting the mesopelagic ocean, plays a crucial role in transporting carbon and nutrients from the surface to depth through the migration of its organisms. Using 18 months of in-situ observations and altimeter sea level data, we reveal for the first time the intraseasonal variations and underlying mechanisms of the DSL and the DV...