Ammonia nitrogen is highly toxic to crustaceans; however, studies investigating the molecular mechanisms underlying its metabolism and excretion in these organisms remain scarce. The present study aims to identify key genes and investigate the molecular mechanisms in response to ammonia nitrogen using RNA sequencing in Scylla paramamosain , a key economic crab species in Asia that is subjected to ammonia nitrogen stress in aqu...

Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-related depression is not yet clear. Previous studies have suggested FMOD as a potential key factor in TBI, yet its association with depression post-TBI and underlying mechanisms are not well understood. Serum levels of FMOD were measured in patients with traumatic brain injury using qPCR. The severity of depres...

Osteoarthritis (OA) is a common disease in middle-aged and elderly people. An imbalance in calcium ion homeostasis will contribute to chondrocyte apoptosis and ultimately lead to the progression of OA. Transient receptor potential channel 4 (TRPV4) is involved in the regulation of intracellular calcium homeostasis. TRPV4 is expressed in primary cilia, which can sense mechanical stimuli from outside the cell, and its abnormal e...