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Leishmaniasis is a neglected tropical disease posing significant global health challenges. Given the limited effective treatment options and associated constraints, many patients are unable to complete therapy. In this study, we report the remarkable leishmanicidal activity of onnamides derived from the marine sponge Theonella sp. against the promastigote form of Leishmania major (IC 50 = 0.2–140 nM) and demonstrate their sele...
Material recycling in a sediment‐starved trench recorded in the Early Cretaceous Shiriya accretionary complex, Northeast JapanNARA Subscribed
Identifying and examining geological processes that have occurred in sediment‐starved trenches of ancient non‐accretionary subduction zones exposed on land are still challenging, because such style of subduction is believed to leave scarce rock records. Our new geological mapping, petrography of coarse clastic rocks, radiolarian and zircon U–Pb dating of the Shiriya accretionary complex in Northeast Japan suggest that the youn...
The DnaA N ‐terminal domain interacts with Hda to facilitate replicase clamp‐mediated inactivation of DnaANARA Subscribed
Summary DnaA activity for replication initiation of the E scherichia coli chromosome is negatively regulated by feedback from the DNA ‐loaded form of the replicase clamp. In this process, called RIDA (regulatory inactivation of DnaA ), ATP ‐bound DnaA transiently assembles into a complex consisting of Hda and the DNA –clamp, which promotes inter‐ AAA + domain association between Hda and DnaA and stimulates hydrolysis of DnaA ‐...