All Articles results 49
· Newest (Page 1/2, per page 25)
Author: Yulan Xu ×Clear All Filters
Search Results
Recent advances in the detection and functional analysis of circRNAs with short-read RNA sequencing-based methodsNARA Subscribed
Circular RNAs (circRNAs) were first identified approximately 50 years ago in pathogenic viroids as single-stranded, covalently closed RNA molecules. Initially considered by-products of splicing, circRNAs are now recognised as an important class of regulatory RNAs involved in microRNA sponging, RNA–protein interactions, and cellular pathways. Their closed-loop structure, generated through backsplicing, confers resistance to exo...
Utilisation of Machine Learning Approaches Improves RNA-Seq Transcriptome Analyses in Alzheimer’s Disease BrainNARA Subscribed
Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively deteriorates a person’s memory, as well as their ability to think and move. It has been reported to be the most common cause of dementia. Alterations in gene expression have been increasingly recognised as key contributors to the onset and progression of AD, driving interest in transcriptomic approaches to better understand the disease at a molecular l...
The comprehensive ten-year fishing ban implemented in the Yangtze River on January 1, 2021, represents a critical ecological conservation measure and national strategic priority in China. Assessment of the ban’s effectiveness is essential to guide future long-term conservation efforts. This study systematically analyzed changes in the stock structure and biomass dynamics of Coilia nasus in the Yangtze River-Poyang Lake waterwa...
Genetic Diversity in Three Sinipercine Fishes Based on Mitochondrial D-Loop and COX1 SequencesOA Marine
Mandarin fish (Siniperca chuatsi), golden mandarin fish (Siniperca scherzeri), and Coreoperca whiteheadi are three important aquaculture species in China facing several threats to their production. Genetic diversity was assessed by sequencing the mitochondrial D-loop and cox1 regions in 207 individuals across nine populations. The genetic diversity analysis, based on the concatenated sequences, revealed that the total haplotyp...
Discovery of Novel Protein-Coding and Long Non-coding Transcripts in Distinct Regions of the Human BrainNARA Subscribed
Recent improvements in the accuracy of long-read sequencing (LRS) technologies have expanded the scope for novel transcriptional isoform discovery. Additionally, these advancements have improved the precision of transcript quantification, enabling a more accurate reconstruction of complex splicing patterns and transcriptomes. Thus, this project aims to take advantage of these analytical developments for the discovery and analy...