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Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategiesNARA Subscribed
Platinum-based chemotherapeutic agents constitute the cornerstone of treatment for a wide range of solid tumors. However, residual platinum can persist in the body long after treatment cessation, leading to progressive accumulation, chronic multi-system toxicity, and significant impairment of patients' quality of life. The insidious onset and lack of specific monitoring methods often lead to the oversight of this treatment-rel...
Warming‐Induced Carbon Vulnerability in Permafrost Forests: A Shift in Q 10 From Continuous to Discontinuous ZonesNARA Subscribed
Permafrost forests harbor vast, climate‐sensitive carbon (C) reservoirs whose vulnerability largely depends on temperature sensitivity of microbial respiration ( Q 10 ). However, substantial uncertainties persist in predicting Q 10 patterns due to complex interactions among multiple ecological factors. Here, we conducted a standardized field survey with controlled incubations across a regional gradient from continuous permafro...