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Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategiesNARA Subscribed
Platinum-based chemotherapeutic agents constitute the cornerstone of treatment for a wide range of solid tumors. However, residual platinum can persist in the body long after treatment cessation, leading to progressive accumulation, chronic multi-system toxicity, and significant impairment of patients' quality of life. The insidious onset and lack of specific monitoring methods often lead to the oversight of this treatment-rel...
Molecular understanding of plant pollination, fertilization, seed development and protoplast regenerationNARA Subscribed
Sexual reproduction in plants is a tightly coordinated process that underpins biodiversity, drives speciation, and serves as a foundation for modern crop improvement. Here, we synthesize recent advances in elucidating the molecular mechanisms governing major reproductive events in flowering plants, including male and female gametogenesis, pollen-pistil communication, double fertilization, embryogenesis, and endosperm-mediated...