As two spatial geographic units that are both independent of each other and closely linked, the land and sea have complex spatial interactions. Therefore, China implements the land-sea coordination policy (LSC) needs to be approached from a more macroscopic, systematic and comprehensive perspective. Based on the interregional externality theory, this study takes the land-sea coordination policy of China as an example, and focu...

Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or functional magnetic resonance imaging to resolve the structure pattern and functional activity during subtraction operation. However, a high resolution of the spatial-temporal understanding of the neural mechanisms involved...

Background Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 mutants are commonly described as the guardian of cancer cells by conferring them drug-resistance and immune evasion. Importantly, p53 mutations have also been identified in RA patients, and this prompts the investigation of its role in RA pathogenesis. Methods The cytotoxicity of disease-modifying a...