Yusuke Inoue results 43
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Improving cognitively healthy survival is important for achieving healthy aging. Therefore, it would be valuable to estimate the future risk of either incident dementia or death in community-dwelling older adults. This study aimed to develop a set of risk prediction models for either incident dementia or death that can be applied according to data availability across diverse clinical settings, using longitudinal data from comm...
In-phase variation along the Nankai trough in the ocean bottom temperature records of DONETNARA Subscribed
Ocean bottom temperature is affected by waves propagating along the seafloor. Understanding fluctuations in ocean bottom temperature caused by such wave phenomena can enhance the accuracy of geophysical observations. If seafloor seismic observation networks such as the Dense Ocean floor Network system for Earthquakes and Tsunamis (DONET), which was installed for earthquake disaster prevention in the Nankai Trough region, can d...
Angiogenic Ability of Extracellular Vesicles Derived from Angio-miRNA-Modified Mesenchymal Stromal CellsNARA Subscribed
Background: Regenerative therapy using extracellular vesicles (EVs) is a promising approach for the supportive treatment of chronic limb-threatening ischaemia. Herein, we examined the angiogenic potential of EVs derived from genetically modified mesenchymal stromal cells (MSCs), focusing on the angio-micro RNAs (miRNAs) in EVs. Methods: Bone marrow-derived MSCs (BM-MSCs) were transfected with lentiviral vectors containing spec...
Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. This cross-sectional study investigated the associations between dietary patterns, dementia, and WMLs in a large, nationwide, multicenter population of older Japanese adults. A total of 8,938 adults (aged ≥ 65; 73 ± 6.3 years old) from the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD...
Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cellsNARA Subscribed
The first-generation pCMViR-TSC, implemented through the promoter sandwich rule, yields 10- to 100-fold higher gene expression than the standard plasmid used with the CMV (cytomegalovirus) or CAG promoter. However, the vector’s shortcomings limit its utility to transient expression only, as it is not suitable for establishing stable transformants in mammalian cells. To overcome this weakness, we here introduce the improved pla...