Photosensitivity is a skin reaction disorder mediated by phototoxic and/or photoallergic mechanisms. The accumulation of porphyrins is generally considered to induce phototoxicity. ATP-binding cassette subfamily G member 2 (ABCG2) has been identified as a transporter of porphyrins and its common variants—p.Gln126Ter (rs72552713) and p.Gln141Lys (rs2231142)—reportedly decrease the function of porphyrin transport in vitro; howev...

Global Water Models (GWMs), which include Global Hydrological, Land Surface, and Dynamic Global Vegetation Models, present valuable tools for quantifying climate change impacts on hydrological processes in the data scarce high latitudes. Here we performed a systematic model performance evaluation in six major Pan-Arctic watersheds for different hydrological indicators (monthly and seasonal discharge, extremes, trends (or lack...

Importance of evaluation of global hydrological models (gHMs) before doing climate impact assessment was underlined in several studies. The main objective of this study is to evaluate the performance of six gHMs in simulating observed discharge for a set of 57 large catchments applying common metrics with thresholds for the monthly and seasonal dynamics and summarize them estimating an aggregated index of model performance for...