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Neuroscience Bulletin · 2026 · Vol. 42 · Issue 3 · Springer
Nr4a2 ( Nurr1 ) is well known to be vital for midbrain dopaminergic neurons. Recent single-cell RNA analyses reveal that Nr4a2 is expressed in lateral cerebral regions, within neurons named L4/L5/L6 IT Car3 . These neurons have attracted intense attention for the molecular mechanisms underlying their development and functions. We classified Car3 neurons into neocortical (Ncx- Car3 ), claustral (CLA- Car3 ), and dorsal endopiri...