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Biomarkers of agingNARA Subscribed
The small-scale event layers in the continental margin contain abundant dynamic environment information, and pose a challenge to the interpretation of continuous sedimentary records, giving geological significance to their accurate identify and possible genesis. Here, pulsed turbidite layers since the last glacial maximum (LGM) in a gravity core in the northwestern South China Sea (SCS) was analyzed to investigate the precisel...
Identification of marine natural product Pretrichodermamide B as a STAT3 inhibitor for efficient anticancer therapyNARA Subscribed
The Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) regulates the expression of various critical mediators of cancer and is considered as one of the central communication nodes in cell growth and survival. Marine natural products (MNP) represent great resources for discovery of bioactive lead compounds, especially anti-cancer agents. Through the medium-throughput screening of our in-house MNP libr...