A systematic chemical investigation of the deep-sea-derived fungus Penicillium limosum ZEN48 resulted in the isolation of four new indole-diketopiperazine alkaloids, limopiperazines A–D ( 1 – 4 ), alongside 16 known analogues ( 5 – 20 ). The structures of the new compounds were determined through comprehensive spectroscopic analysis, quantum chemical calculations, X-ray crystallography, and biogenetic considerations. Limopiper...

Purpose To investigate the differences in foot kinematics during gait between adults with asymptomatic and symptomatic flatfoot. Methods The study included 10 participants (six males and four females, aged 25.7 ± 6.5 years) with symptomatic flatfoot and 10 participants (eight males and two females, aged 21.2 ± 1.0 years) with asymptomatic flatfoot. Multi-segment foot kinematics were captured during barefoot gait analysis using...

Nowadays, diarrheic shellfish toxicity (DSP) toxin and microplastics (MPs) are commonly found in coastal waters worldwide. Due to their widespread use, their persistence and toxicity, they may induce adverse effects on Mytilus coruscus . However, the underlying toxic mechanisms of DSP and MPs on M. coruscus remain unclear. This study explored the physiological index and transcriptome change of the digestive gland of adult M. c...