Protein kinase C delta (PKCδ), a calcium-independent novel PKC isoform, is increasingly recognized as a compartmentalized regulator of stress signaling in the central nervous system. Through tyrosine phosphorylation, subcellular translocation, regulation of its expression, and caspase-3-dependent proteolytic activation, PKCδ can convert transient adaptive responses into sustained oxidative, mitochondrial, inflammatory, and nuc...

This study aims to elucidate the biological effects of Baicalein (BA) on intervertebral disc degeneration (IDD) and the potential mechanisms involved. Network pharmacology analysis was performed to identify the core targets and signaling pathways responsible for the therapeutic effects of BA on IDD. In vitro validation was carried out using IL-1β-stimulated nucleus pulposus cells (NPCs). Cell viability, apoptosis, inflammatory...

Breast cancer is the most frequently diagnosed cancer in women worldwide and one of the most common malignancies in dogs. Notable clinical, hormonal and molecular similarities between both species suggest that dogs may serve as a valuable comparative oncology model. Alterations in lipid homeostasis and metabolism are closely associated with the acquisition of cancer hallmarks. In this study, a comparative proteomic analysis of...

Triple-negative breast cancer (TNBC) is an aggressive malignancy defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). These molecular characteristics render targeted therapies less effective and contribute to poor clinical outcomes. Towards this, we studied the electroporation-mediated delivery of resveratrol, a polyphenolic compound with pleiotropic...

This study examined how cationic α‑helical antimicrobial peptides such as protamine exchange between the aqueous phase and the transmembrane β‑barrel porin OmpF ( E. coli ) at the single‑molecule level. High‑resolution conductance recordings in planar lipid bilayers revealed clear voltage‑ and concentration‑dependent ion current blockages, consistent with transient peptide interactions within the OmpF lumen. Peptide length inf...