Alzheimer’s disease (AD) is increasingly recognized as a neurodegenerative disorder associated with chronic low-grade inflammation and age-related immune dysregulation. Microglial-derived extracellular vesicles (MDEVs) are emerging as important mediators of neuroimmune communication and potential biomarkers reflecting pathological processes occurring within the central nervous system (CNS). However, how EV-associated inflammat...

Workplace stress is an increasingly recognized determinant of both workforce well-being and healthy aging. However, few longitudinal studies have systematically integrated stress assessment into large occupational cohorts with an explicit focus on aging processes. The Semmelweis Study, launched in 2024, addresses this gap by embedding validated stress assessment tools into a comprehensive, multidisciplinary framework designed...

The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alzheimer’s disease) and A−T+ (suspected non-Alzheimer’s tauopathy), remains unexamined despite their differential impact on LC-mediated modulation and cortical network inte...

Frailty and cognitive impairments frequently co-occur in older adults. It remains unclear whether this overlap reflects shared underlying biological mechanisms or parallel but distinct disease pathways. We hypothesize that physical weakness and cognitive impairment share circulating markers already in an early disease stage. We therefore recruited and analyzed a relatively healthy population with partially overlapping pre-frai...

Osteoporosis, characterized by low bone mineral density (BMD) and increased fracture risk, is common yet underdiagnosed in older adults. Medications such as corticosteroids, levothyroxine, and antiepileptic drugs are well-documented contributors to BMD loss. This study examines how long-term use of these medications affects osteoporosis prevalence, specifically focusing on sex and age differences. This retrospective electronic...

Family dogs’ human-analogue attachment to the owner has long been recognised; however, how this dog–owner attachment develops and changes with age remains an open question. We examined age-related variation and the effect of training experience on the attachment behaviour in family dogs ( N = 222) using the Strange Situation Test (SST). Across three age groups (puppy–juvenile, adult, and senior dogs), dogs were assessed by s...