Noccaea caerulescens is a metal hyperaccumulator plant species with the capacity to accumulate high concentrations of zinc (Zn), cadmium (Cd) and nickel (Ni). Several candidate genes have so far been associated with accumulation and tolerance of these metals, but gene function analysis has been cumbersome in the absence of an efficient stable plant transformation method for N. caerulescens . A previously identified mutation in...

Functional validation of candidate genes in congenital anomalies of the kidneys and urinary tract (CAKUT) and other disorders is essential for translating genetic discoveries into clinical applications. Conditional knockout mouse models are indispensable for studying gene function in complex organ systems. The Short Conditional intrON (SCON) system accelerates the generation of such models by inserting the artificial SCON into...

Despite being a main protein supplier in the human diet, wheat proteins represent a health challenge for some people. Besides the well-known celiac disease caused by gluten proteins, there is an occupational illness known as baker´s asthma. Amylase/trypsin inhibitors (ATIs) have been reported to be the major group of wheat proteins responsible for bakers´ asthma. As part of the characterization of stress-tolerant (HB4 ® techno...