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Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applicationsNARA Subscribed
Delivering drugs effectively to the ocular surface is challenging due to rapid clearance mechanisms, including blinking, tear turnover, and protective barriers of the conjunctival and corneal epithelium. As a result, conventional options such as eye drops often fail to provide sustained therapeutic effects and require frequent dosing, leading to reduced patient compliance. Mucoadhesive nanofiber systems offer a promising solut...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Sexual reproduction of zooxanthellate scleractinian corals in the Eastern Tropical Pacific (ETP) is influenced by the interactive effects of regional and local oceanographic conditions, as well as a variety of other environmental factors. Differences in spatial and temporal gamete development and reproductive patterns of three widespread scleractinian corals of this region— Pocillopora damicornis (branching colony morphology,...
Blue Lake, a remote sub‐alpine lake, in Nelson Lakes National Park, New Zealand, has exceptional optical purity. Horizontal sighting range (‘visibility’) on six visits approached 80 m, the theoretical limit based on accepted light‐attenuation coefficients for pure water, making Blue Lake the most visually clear freshwater yet reported. Blue Lake is characterized by blue‐violet hues seen only in the clearest natural waters. Lig...
This paper provides an overview of the Motueka integrated catchment management (ICM) research programme. This research was based on the thesis that achieving ecosystem resilience at a catchment scale requires active measures to develop community resilience. We define a generic adaptive planning and action process, with associated knowledge management and stakeholder involvement processes, and illustrate those processes with ob...
Modelling the time course of shade, temperature, and wood recovery in streams with riparian forest restorationNARA Subscribed
Action is increasingly being taken in New Zealand and elsewhere to restore ecological function to streams through planting of riparian zones. We used simulation modelling to explore the relative performance of three strategies to restore the riparian zone of a pastoral stream to native forest by: (1) passive regeneration; (2) planting then abandonment of a Pinus radiata plantation; and (3) active restoration by planting select...
The mechanisms of interaction between stream life and habitat are often complex and poorly understood. We explored the response of a freshwater crayfish ( Paranephrops planifrons ) to the functions of large wood with a view towards possible future use of wood in stream restoration in New Zealand. We compared three sub‐reach types within a native forest stream in the central North Island, New Zealand; complex wood‐rich, simple...
Water quality impact of a dairy cow herd crossing a streamNARA Subscribed
The water quality impact of a herd of 246 dairy cows crossing a stream ford was documented. Two cow crossings produced plumes of turbid water associated with very high concentrations of faecal indicator bacteria ( Escherichia coli ) and high suspended solids (SS) and total nitrogen (TN). On the first crossing, towards the milking shed, the cows were tightly‐bunched and produced a sharp spike of contamination ( E. coli peaking...
Land use effects on habitat, water quality, periphyton, and benthic invertebrates in Waikato, New Zealand, hill‐country streamsNARA Subscribed
Water quality, habitat, and biota were compared during spring amongst c. 100 m reaches on 11 streams draining pasture, native (podocarp‐broadleaf) forest, and exotic pine forest established on pasture 15 years previously. Differences were greatest between the pasture and native forest streams. Only 1–3% of incident light reached native and pine forest streams whereas 30% reached pasture streams. Pasture streams had 2.2°C highe...
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