The insidious onset and progression of sarcopenia make it vital to understand the early skeletal muscle changes and explore therapies to slow its progression. This study explored the gastrocnemius remodeling at an early stage of aging (14 months of age) and the effects of lifelong aerobic exercise. For that, 2-month-old male Wistar rats underwent a 12-month treadmill exercise program. Sedentary age-matched, young sedentary, an...

We evaluated endolithic fungal diversity associated with rocks sampled at the polyextreme Brazilian São Pedro and São Paulo archipelago using a DNA amplicon metagenomics approach. We detected 808,547 fungal DNA reads grouped into 92 amplicon sequence variants (ASVs). The rocks sampled were geologically characterized as mylonitized peridotites, serpentinized peridotites, and carbonate-matrix sedimentary breccias. Ascomycota was...

Yeasts can produce microbial oil from hydrophobic substrates such as glycerol, a byproduct of the biodiesel industry that is often undervalued in the market. Yarrowia lipolytica is capable of degrading glycerol and is considered a model organism for studying lipid accumulation. Different yeast strains and culture conditions can result in varying lipid yields with distinct fatty acid profiles. Thus, in this study, five strains...

Microplastics are an emerging contaminant in marine ecosystems worldwide. This study evaluated the abundance of microplastics, their relationship with sediment type, and their ingestion by macroinvertebrates in the Eastern South Pacific Ocean and the Southern Caribbean Sea during the rainy and dry seasons. A granulometric analysis was performed applying a Pearson correlation matrix, and microplastics were extracted using the d...

Purpose Strongyloidiasis is an intestinal helminthiasis that can induce structural alterations in the intestinal mucosa during infection. The present study evaluated histomorphometric alterations of the small intestine in mice experimentally infected with Strongyloides venezuelensis and treated with Rosmarinus officinalis essential oil. Methods Infected animals were treated orally with R. officinalis essential oil (200 or 400...

Cryptic diversity in mesopelagic fish is increasingly documented across the Indo-Pacific, but remains understudied in the Red Sea, a region known for its high endemism and unique ecological conditions. We investigated cryptic diversity in Benthosema spp. and population genetic structure in the two most abundant mesopelagic fishes in the eastern Red Sea, the Benthosema pterotum species complex and the endemic Vinciguerria mabah...

Earth's biodiversity is central to ecosystem health and resilience, providing essential functions and services. The Red Sea is a recognised marine biodiversity hotspot with high endemism and unique environmental conditions that support extensive but poorly resolved biodiversity. Here, we applied metagenomic analyses to sediment samples collected from coastal to deep‐sea environments during the Red Sea Decade Expedition 2022 to...

The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...