Background Branch pulmonary artery (PA) stenosis is a significant congenital heart defect causing elevated pulmonary blood pressure, trans-stenotic pressure drop, and abnormal differential blood flow to the lungs. We propose combined pressure-flow diagnostic parameters, pressure drop coefficient ( CDP ) and normalized energy loss ( Ē loss ) for improved delineation of stenosis severity. In extension to our previous benchtop ex...

Rationale Affective behavioral effects of kappa-opioid receptor (KOR) stimulation have been found to vary between the rostral and caudal nucleus accumbens (NAc) shell, but this has so far only been demonstrated in males. Objectives To examine the effects of KOR activation in subregions of the NAc shell on affective and motivated behavior in females. Methods In one group of Long-Evans rats, females were given access to 20% etha...

Measurement of methane fluxes (FCH 4 ) from natural systems, such as wetlands, has lagged far behind carbon dioxide fluxes. Short and fragmented wetland FCH 4 data limit our ability to assess its long‐term dynamics and potential climate feedbacks. Extrapolating short‐term FCH 4 records to recent decades remains challenging for both process‐based models and data‐driven machine learning (ML) approaches. Here, we develop a knowle...

Epigenomic changes are a hallmark of aging, and DNA methylation (DNAm) has emerged as the most reliable molecular marker of an individual's age. Genome‐wide patterns of age‐associated hypo‐ and hypermethylation have been applied to generate predictive models (i.e., “epigenetic clocks”) capable of estimating chronological age in an increasingly diverse set of species including many mammals, a few birds, a reptile, and several b...

Forested wetlands provide a valuable potential sink for atmospheric carbon, with rates varying between tree communities. Previous studies found that topographic position within the Congaree Swamp (South Carolina, USA) influences flooding regimes, sedimentation processes, and forest community types. We measured aboveground net primary productivity (ANPP) for four distinct tree community types situated within an elevational grad...

Migratory fish species are highly vulnerable to stream fragmentation. Potamodromous golden perch ( Macquaria ambigua ) inhabit the barrier-laden Murray–Darling Basin (MDB), Australia’s largest river system, and its lifecycle includes a requirement for uninterrupted stretches of flowing water habitat. Owing to these barriers, large-scale connectivity in many regions is limited to periods of high flow events that facilitate barr...