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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Human activities can impact the genetic diversity of populations, making them more vulnerable to extinction. Rare species are at an increased risk of negative genetic consequences of human activities, but understanding genetic diversity in rare species requires comparison to more common congeners. Hybridization, a common phenomenon in plants, can provide genetic rescue of genetically depauperate populations or put rare species...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Micro‐Refuges or Ecological Traps: Context‐Dependent Effects of Rock Pools on Intertidal Biodiversity Across LatitudesNARA Subscribed
Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...
Guidelines for producing integrated 210Pb and 14C age-modelsNARA Subscribed
Motor segmentation: a key neuromuscular impairment in people with parkinson’s diseaseNARA Subscribed
Healthy adults (OA) achieve rapid isometric force production with a brief, high amplitude burst of neural excitation. In some people with Parkinson’s disease (PwPD), transient reductions in neural excitation (motor segmentation) reduce rates of force development (RFD) and prolong contractions. Segmentation has strong relationships with time and rate-based measures of slowing in rapid contractions and is reliably measured from...
Pre-adult political experiences and political participationNARA Subscribed
Environmental and Geographic Conditions on the Breeding Grounds Drive Bergmannian Clines in NightjarsNARA Subscribed
Aim To evaluate (1) whether three migratory nightjar species (Family Caprimulgidae) adhere to Bergmann's rule, (2) whether environmental factors on the breeding or wintering grounds determine body size, and (3) which mechanistic hypotheses best explain Bergmannian patterns in body size. Location North and South America; Europe and Africa. Taxon Eastern whip‐poor‐will ( Antrostomus vociferus ), Common nighthawk ( Chordeiles min...
Mapping Oak (Quercus spp.) Regeneration Potential Within the Nantahala National ForestNARA Subscribed
Forest mesophication threatens the regeneration and potential future perpetuation of oak ( Quercus spp.) forests throughout southern Appalachia and eastern United States (US). We explored methods to produce stand-scale oak site suitability maps, within the Nantahala National Forest in North Carolina, which can be used to prioritize site-specific treatments to allow for oak regeneration and recruitment using silvicultural strat...
Glacial erratics are geologically distinctive rocks transported away from their source area by ice sheets and deposited in lithologically different bedrock areas. They have attracted much scientific curiosity with >24 000 observations across the British Isles. A common misinterpretation is that they took a nearly direct line of transport from source to resting position, neglecting to change ice flow directions during ice sheet...
Cruel Summer (and Autumn): Humid Heat Trends, Extremes, and Mechanisms in the Southeast United StatesNARA Subscribed
Humid heat has increased in frequency, intensity and duration in many locations across the globe, particularly those with warm and moist climates like much of the Southeast United States. This study employs an established wet bulb globe temperature (WBGT) estimation formula and high‐resolution reanalysis data to develop a custom gridded WBGT dataset for the Southeast. Subsequently, summer and autumn WBGT (humid heat) trends an...