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Introduction Toxicologists may use high dose n-acetylcysteine (HD-NAC) for early-treated high-risk acetaminophen ingestions (EHRAI) given concerns over standard NAC (S-NAC) dosing’s efficacy. We utilize the novel, clinically relevant outcome of mean additional 16-hour NAC maintenance infusions (NMI) to evaluate differences in treatment duration for EHRAI patients treated with S-NAC versus HD-NAC. Methods Retrospective multista...
High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intakeNARA Subscribed
Rationale Hormonal fluctuations throughout the estrous cycle are hypothesized to influence drug-related behaviors. Preclinical models show that some cocaine-related behaviors are influenced by the estrous cycle. However, the extent to which the estrous cycle modulates cocaine self-administration in outbred heterogeneous stock (HS) rats is unknown. Objectives We aimed to examine the relationship between estrous phases and cocai...
Blue carbon ecosystems, such as mangroves, tidal marshes, and seagrasses, are important for climate mitigation. As carbon sinks, they often exhibit higher per hectare carbon storage capacity and sequestration rates than terrestrial systems. These ecosystems provide additional benefits, including enhancing water quality, sustaining biodiversity, and maintaining coastal resilience to climate change impacts. The widespread loss o...
Microscale analysis of the fish Knightia eocaena taphonomy: Implication of a preserved microbial communityNARA Subscribed
Microbial communities are important components controlling the fidelity of fossil fish preservation. The Eocene Green River Formation lagerstätten, exceptionally preserved fossil deposits, provides an opportunity to examine the role of microbial communities and their metabolic byproducts, such as chemical precipitated in this spectacularly preserved fish deposit, famous throughout the world. Field emission scanning electron mi...
Laboratory evaluation of potential climate change impacts on the larval metamorphosis of Pacific lamprey (Entosphenus tridentatus)NARA Subscribed
Organisms that undergo metamorphosis can be particularly vulnerable to environmental changes. However, if these transitions are ignored as an explicit life stage in evaluations and models, such threats can be overlooked. In lamprey, larvae that achieve enough energy storage appear to metamorphose when exposed to cold winter water temperatures followed by a rise in spring temperature. Winters of the Pacific Northwest (USA) are...
Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brainNARA Subscribed
Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality’s invasive nature. This study substantially expands the subject pool compared to existing literature, to create a mult...