Novel treatments that act beyond the conventionally targeted monoamine system are urgently needed to provide more effective relief for patients with major depressive disorder. Pentoxifylline (PTX) is a phosphodiesterase inhibitor with potent anti-inflammatory and antioxidant effects, with additional pleiotropic effects. This is the first systematic review and meta-analysis to examine the role of PTX in major depressive disorde...

The investigation of the toxic potential of a newly introduced herbicide, Florpyrauxifen-benzyl (FPX), on Nile tilapia ( Oreochromis niloticus ) was the aim of this study. For 96 h, the median lethal concentration (LC 50 ) was assessed in fish juveniles using the Probit analysis following the exposure to five concentrations of FPX (2–3 ppm). For investigating some mechanisms of FPX toxicity, fish were allocated into three grou...

A novel mesoporous magnetic biochar (MBC) was prepared, using a randomly growing plant, i.e., common reed, as an exporter of carbon, and applied for removal of methylene blue (MB) from aqueous solutions. The prepared sorbent was characterized by nitrogen adsorption/desorption isotherm, saturation magnetization, pH of point of zero charges (pH PZC ), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microsc...

The objective of this study was to investigate whether the neurotoxic effects caused by methotrexate (MTX), a frequently used chemotherapy drug, could be improved by administering Spirulina platensis (SP) and/or thymoquinone (TQ). Seven groups of seven rats were assigned randomly for duration of 21 days. The groups consisted of a control group that was given saline only. The second group was given 500 mg/kg of SP orally; the t...

In this work, cotton stalks ( Gossypium barbadense ) and date palm stones ( Phoenix dactylifera ) have been used as biosorbents to remove cadmium; Cd(II), lead; Pb(II), and zinc; Zn(II) from mono- and multi-solutions. Each biosorbent was characterized using SEM-EDX, and FT-IR. The findings showed that pH, dose, contact time, metal concentration, and particle size affect the treatment process. The adsorption pattern was Pb(II)...

Coronavirus disease 2019 (COVID-19) has a wide-ranging spectrum of clinical symptoms, from asymptomatic/mild to severe. Recent research indicates that, among several factors, a low vitamin D level is a modifiable risk factor for COVID-19 patients. This study aims to evaluate the effect of vitamin D on hospital and laboratory outcomes of patients with COVID-19. Five databases (PubMed, Embase, Scopus, Web of Science, and Cochran...

This study aimed to examine the side effects of selected neonicotinoids (Acetamiprid, Aceta, and Imidacloprid, Imid) on Oreochromis niloticus juveniles. The acute toxicity, Probit method, revealed an LC 50 of 195.81 and 150.76 ppm for Aceta/96 h and Imid/72 h respectively. The fish were divided into three groups that were exposed, for 21 days (n = 5/replicate), to 1/10 of the LC 50 of either neonicotinoids, however, the third...

The objectives of this research were to contrast the expression values of heat shock protein (HSP70) and interleukins 2, 6 and 12 (IL 2, IL 6 and IL 12) genes in summer and winter in two different locations in Egypt (Alexandria zone and Matrouh zone) to deduce changes in thermo-physiological traits and biochemical blood metabolites of Barki sheep. A total of 50 ewes (20 in Alexandria and 30 in Matrouh) were individually blood...