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Sources of Variability in Intracranial Aneurysm Model Reconstruction and Evaluation: A Systematic InvestigationNARA Subscribed
Purpose The intracranial aneurysm (IA) model reconstruction is critical for pathophysiology diagnosis and computational simulations. This study aimed to quantify the impact of segmentation thresholds and software platforms on the reconstruction of IA geometry as well as the impact of inter-user variability on the assessment of morphology. Methods 600 IA models were reconstructed from 100 patient DSA datasets using Materialise...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Chronic Alcohol Drinking Impairs Recognition Memory And Insulin-Associated Genes In The Medial Prefrontal CortexNARA Subscribed
Chronic alcohol drinking increases susceptibility to cognitive impairment; however, the underlying mechanisms remain unclear. In this study, we investigated the effects of chronic alcohol drinking on working and recognition memory in a Marchigian Sardinian alcohol-preferring (msP) rat line. Due to interest in insulin-based medications for alcohol use disorder, we examined insulin/insulin-like growth factor 1 (IGF-1) genes in t...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
A Global Comparison of Stream Diatom Beta Diversity on Islands Versus Continents Across ScalesNARA Subscribed
Aim To evaluate the patterns of stream diatom beta diversity in islands versus continents across scales, to relate community similarities with spatial and environmental distances and to investigate the role of island characteristics in shaping insular diatom beta diversity. Location Africa, America, Europe and the Pacific. Time Period Present. Major Taxa Studied Stream diatoms. Methods We compared diatom beta diversity between...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Stream diatom community assembly processes in islands and continents: A global perspectiveNARA Subscribed
Aim Understanding the roles of deterministic and stochastic processes in community assembly is essential for gaining insights into the biogeographical patterns of biodiversity. However, the way community assembly processes operate is still not fully understood, especially in oceanic islands. In this study, we examine the importance of assembly processes in shaping diatom communities in islands and continents, while also invest...
Stream diatom biodiversity in islands and continents—A global perspective on effects of area, isolation and environmentNARA Subscribed
Aim The species–area relationship (SAR) is one of the most distinctive biogeographic patterns, but global comparisons of the SARs between island and mainland are lacking for microbial taxa. Here, we explore whether the form of the SAR and the drivers of species richness, including area, environmental heterogeneity, climate and physico‐chemistry, differ between islands and similarly sized areas on mainland, referred to as conti...
Estuaries are the receiving environment for catchment‐derived contaminants, the fate of which depends on the interplay between the estuarine geomorphology and hydrodynamics. In large estuaries, biophysical processes are spatially and temporally‐diverse, which makes understanding and managing the impact of human activities challenging. Here we use two common modelling approaches to explore the advantages and limitations of biop...
Identifying individual ungulates from fecal DNA: a comparison of field collection methods to maximize efficiency, ease, and successNARA Subscribed
Non-invasive genetic sampling can facilitate the identification of individual animals across a landscape, with applications to management and conservation. Fecal material is a readily available source of DNA, and various methods exist for collecting fecal samples for DNA preservation. In particular, swab methods offer considerable promise, but their utility in real-world field contexts remains relatively untested. We systemati...
Species‐level predation network uncovers high prey specificity in a Neotropical army ant communityNARA Subscribed
Army ants are among the top arthropod predators and considered keystone species in tropical ecosystems. During daily mass raids with many thousand workers, army ants hunt live prey, likely exerting strong top‐down control on prey species. Many tropical sites exhibit a high army ant species diversity (>20 species), suggesting that sympatric species partition the available prey niches. However, whether and to what extent this is...
Effect of Coastal Erosion on Storm Surge: A Case Study in the Southern Coast of Rhode IslandOA Marine
The objective of this study was to assess the effect of shoreline retreat and dune erosion on coastal flooding in a case study located in the southern coast of Rhode Island, USA. Using an extensive dataset collected during 2011, an ADCIRC model was developed to simulate the propagation of storm surge in the coastal areas, including coastal inlets and ponds. A simplified methodology, based on the geological assessment of histor...
A road map for molecular ecologyNARA Subscribed
The discipline of molecular ecology has undergone enormous changes since the journal bearing its name was launched approximately two decades ago. The field has seen great strides in analytical methods development, made groundbreaking discoveries and experienced a revolution in genotyping technology. Here, we provide brief perspectives on the main subdisciplines of molecular ecology, describe key questions and goals, discuss co...