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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Synthesis, Characterization, and Use of Magnesium-Activated Biochar for Nitrate Removal from Aqueous SolutionsNARA Subscribed
Highlights Premodification of biochar with metal salts can be an effective strategy to prepare effective adsorbents. Extensive physicochemical and structural characterizations were performed to delineate the properties of magnesium-modified biochar. Magnesium improved the physical and surface characteristics of the biochar. Magnesium-loaded biochar demonstrated promising potential as an adsorbent for nitrate. Multiple pathways...
A balanced approach to the potential of octopus aquacultureNARA Subscribed
Effect of muscarinic blockade on the speed of attention shifting, read-out delays and learningNARA Subscribed
The study aimed to investigate to what extent blockade of muscarinic receptors affects the speed of endogenous versus exogenous attentional shift times, and how it affects learning of attention shifting, cue detection and signal readout. Subjects viewed an array of 10 moving clocks and reported the time a clock indicated when cued. Target clocks were indicated by peripheral or central cues, including conditions of pre-cuing. F...
Fish meal (FM) and fish oil (FO) are vital components commonly used in feed formulations. However, their supply, which generally comes from capture fisheries, is being exhausted, necessitating the exploration of sustainable alternatives. In a two-part study, the first part evaluated the FM and FO derived from smoked salmon by-product (SSBP) over a 12-week accelerated shelf-life test, comparing their lipid oxidation, amino acid...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Positive Feedback on Climate Warming by Stream Microbial Decomposers Indicated by a Global Space‐For‐Time Substitution StudyNARA Subscribed
Decomposition of plant litter is a key ecological process in streams, whose contribution to the global carbon cycle is large relative to their extent on Earth. We examined the mechanisms underlying the temperature sensitivity (TS) of instream decomposition and forecast effects of climate warming on this process. Comparing data from 41 globally distributed sites, we assessed the TS of microbial and total decomposition using lit...
Postglacial Recolonization of the Southern Ocean by Elephant Seals Occurred From Multiple Glacial RefugiaNARA Subscribed
The Southern Ocean is warming more rapidly than other parts of our planet. How this region's endemic biodiversity will respond to such changes can be illuminated by studying past events through genetic analyses of time‐series data sets, including historic and fossil remains. Archaeological and subfossil remains show that the southern elephant seal ( Mirounga leonina ) was common along the coasts of Australia and New Zealand in...
Vertical walls of submarine canyons represent features of high conservation value that can provide natural areas of protection for vulnerable marine ecosystems under increasing anthropogenic pressure from deep-sea trawling. Wall assemblages are spatially heterogeneous, attributed to the high environmental heterogeneity over short spatial scales that is a typical feature of canyons. Effective management and conservation of thes...
There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and...
Methamphetamine-induced lethal toxicity in zebrafish larvaeNARA Subscribed