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Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) haploinsufficiency is an inborn error of immunity characterized by immune dysregulation, autoimmunity, lymphoproliferation, and an increased risk of malignancy. While susceptibility to oncogenic viral infections has been proposed, the relationship between CTLA-4 haploinsufficiency and human papillomavirus (HPV)-driven carcinogenesis remains poorly characterized. We describe...
Acoustic signals in anurans are classic models for understanding how endocrine mechanisms regulate courtship behavior. However, our understanding of how steroids influence male calling performance remains limited because most studies examine single hormones or isolated call traits. Here we quantified three plasma steroids—testosterone (T), estradiol (E 2 ), and corticosterone (CORT)—from male Cope’s gray treefrogs ( Hyla chrys...
The purpose of this study was to investigate the prevalence of relative age effects (RAEs) within and between U18, U21 and professional senior squads, that compete in the highest (respective) leagues within England. Birthdate, playing position and age (years) of U18 ( n = 487), U21 ( n = 350), and senior ( n = 396) players from squads competing in the highest divisions of their respective age groups were obtained. Moreover, na...
It’s the effort that counts: female gray treefrogs ignore differences in call duration and rate when calling efforts are equalNARA Subscribed
Females commonly exhibit directional preferences for males that produce more exaggerated, elaborate, or energetic signals. Key questions remain regarding individual variation in the expression of such preferences, particularly when performance related trade-offs in signaling occur in social environments (e.g., leks and choruses) where males dynamically compete for females. In this study of Cope’s gray treefrog ( Hyla chrysosce...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Detecting changes in forest soil carbon stocks is critical for compiling national carbon budgets, yet remains challenging due to high spatial variability and relatively small temporal changes. Here, we use data from Canada's National Forest Inventory (NFI), which includes repeated measurements of organic and mineral soil horizons across 532 plots. We quantified within‐ and between‐plot variability in soil carbon properties, as...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Exploring the data demands and global opportunities for reconstructing morphological responses to climate changeNARA Subscribed
There is growing evidence that morphological change is a widespread response to the warming climate. The empirical basis for understanding this process has, to date, largely been correlative analyses of morphological time series. However, it is not clear what constitutes sufficient temporal sampling for assessing long-term morphological change. We analyzed two long-term high-quality morphological datasets, one including 33 spe...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Your brain doesn’t look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-oldNARA Subscribed
The cognitively-intact oldest-old (85 +) may be the most-resilient members of their birth cohort; due to survivorship effects (e.g., depletion of susceptibles), risk factors associated with brain aging biomarkers in younger samples may not generalize to the cognitively-intact oldest-old. We evaluated associations between established aging-related risk factors and brain-predicted age difference (brainPAD) in a cross-sectional c...
Effects of Biodiversity Loss on Freshwater Ecosystem Functions Increase With the Number of StressorsNARA Subscribed
A multitude of anthropogenic stressors drive biodiversity loss and alter ecosystem functioning. Freshwaters, which contribute disproportionally to global biodiversity and biogeochemical cycles, are particularly threatened. Although the relationship between biodiversity and ecosystem functions (BEF) is generally well‐established, especially in terrestrial ecosystems, the role of multiple, co‐occurring stressors in modulating th...
Global wood harvests have steadily increased over the last several decades and are projected to continue growing to match demand for wood products. How forest managers respond to changes in wood demand depends not just on timber prices and production costs but also on competition with other land uses, changes in forest productivity, and land use policies. Wood demand projections are sensitive to assumptions about socioeconomic...