Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elucidated. We investigated whether intracerebral GA administration, alone or combined with quinolinic acid (QA), a pro-inflammatory intermediate of the kynurenin...

Nutrition is a key determinant of performance, carcass traits, and production efficiency in beef cattle. In this context, feed additives have emerged as a promising strategy to enhance nutrient utilization and reduce production costs. We aimed to evaluate the effects of replacing urea with a product extruded urea enriched with essential oils (NFeed ® ) on nutrient intake, performance, blood parameters, and feed cost in feedlot...

Process-based agro-hydrological models are essential tools for assessing crop growth and yield under contrasting management and environmental conditions. This study assessed the performance of the coupled Soil-Water-Atmosphere-Plant and World Food Studies Simulation Model (SWAP–WOFOST) to simulate cotton ( Gossypium hirsutum L., cv. FiberMax 975 Wild Strike ® ) growth and yield under tropical Cerrado conditions in western Bahi...

Cryptococcus neoformans is an encapsulated fungal pathogen characterized by a thick polysaccharide capsule, primarily composed of glucuronoxylomannan (GXM), which represents its major virulence factor and a key target for immunodiagnosis. Mimetic peptides that reproduce GXM epitopes may provide standardized, stable alternatives to native polysaccharide antigens for diagnostic and therapeutic applications. This study aimed to i...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

This study evaluated the effects of increasing inclusion levels of biological silage produced from tambaqui ( Colossoma macropomum ) by-products (BST) in diets of commercial hens at different ages. A completely randomized design in a 2 × 5 factorial arrangement was adopted, comprising two hen ages (23 and 83 weeks) and five BST inclusion levels (0, 1, 2, 3, and 4%), with four replicates of six birds per treatment. Moderate BST...

Coastal dune systems are increasingly affected by land use changes and urbanization, which alter aeolian morphodynamics and reduce sediment supply. This study investigates the multidecadal evolution of a coastal dune system in northeastern Brazil, comparing a period of minimal human influence (1958–1970 s) to one marked by significant anthropogenic intervention (1980s–2025). A multitemporal approach combining remote sensing, f...

Lectins are carbohydrate-binding proteins involved in diverse biological processes and with increasing relevance in biotechnological applications. In this study we report the structural characterization of a lectin from the marine red alga Amansia multifida (AML). Mass spectrometry analysis revealed two major isoforms with molecular masses of 28,388 Da and 28,661 Da. The primary structure of a lectin with a molecular weight of...

Microbially-mediated transformations are important for removing wastewater chemicals in rivers. In-stream degradation rates are likely to be affected by channel morphology and size because these factors determine the extent of chemical contact between the water column and the microbial community in fixed biofilms, where most microbially-mediated processes are expected to take place. We hypothesize that transformation rate cons...

This study documents an ecotoxicological evaluation of bottom sediments ( n = 21) from a tropical lagoon complex performed in the Itaipu-Piratininga system (Rio de Janeiro State), an impacted urban tropical estuary. To achieve this purpose, three lines of evidence were adopted: sediment characterization, metal contamination and toxicity to tropical species (bioassays with mussels Perna perna , tanaids Kalliapseudes schubartii...

The emergence of new viral strains has been frequently associated with the onset of outbreaks in different epidemiological settings. This study investigated an acute gastroenteritis (AGE) outbreak, which occurred at a university campus in southern Brazil, in 2024, affecting approximately 30–40% of undergraduate students, with over 400 reported cases. The objectives were to describe the epidemiological and molecular features of...

Bees are essential for ecosystem functioning, pollinating many wild and crop plant species. Predicting which species are most vulnerable to global changes, and how their loss may impact ecosystems and human well-being, is critical. Comprehensive information on bee response and effect traits is fundamental to these assessments. However, the Raunkiærian shortfall—insufficient trait data—remains significant for bees, particularly...