Background Undergraduate students constitute a relevant population for investigating genetic and body weight-related factors associated with vitamin D deficiency. This study aimed to assess the associations of the VDR BsmI single nucleotide polymorphism (SNP) and body weight status, including obesity, with vitamin D deficiency in undergraduate students. Methods and Results This cross-sectional study included biochemical and ge...

Background Currently, no single biomarker can reliably identify preclinical Alzheimer’s disease (AD), particularly at or before the mild cognitive impairment (MCI) stage. Given the heterogeneity of MCI, integrative approaches are needed to improve early risk stratification. Objectives (i) To derive robust latent cognitive components from a multicenter, clinically defined MCI cohort using principal component analysis (PCA); (ii...

Background Breast cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the need for more selective and effective therapies. This study aimed to identify and validate novel anticancer peptides targeting Luminal A (MCF-7) and triple-negative (MDA-MB-231) breast cancer subtypes using an integrated in silico and in vitro approach. Methods Overexpressed proteins in each cell line were identif...

Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. However, their clinical application is significantly hindered by their poor transport across the blood-brain barrier (BBB) and their limited diffusion within the brain parenchyma. While significant efforts have been oriented to tackle the first barrier, the challenge of efficient brain diffusion remains large...

Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...

Wildlife health assessments offer critical insights in applied ecological research, but their interpretation is often limited by missing complementary data. There is heightened need for such data for European harbor seals ( Phoca vitulina vitulina ) given their recent population decline. We investigated trends in and hematological markers of health and survival of pre‐ and post‐ weaned harbor seal pups using a 10‐year rehabili...

Α-synuclein aggregation is the pathological feature of several neurodegenerative disorders, including Parkinson’s disease. The aggregates can diffuse within brain areas, and their toxicity has been proven in both cellular and animal models. Given that, recent therapeutic strategies have been focusing on the identification of compounds able to promote the degradation of aggregates or, at least, to prevent the aggregation proces...

We studied the drivers of population‐genetic structuring and genetic diversity in specialist parasites based on whole‐genome resequencing data from 82 Echinophthirius horridus seal louse individuals sampled from 12 ecologically and behaviourally different phocine seal species, subspecies and populations across the Holarctic. We found that the main genetic disjunctions in E. horridus lice occur across seal host species and subs...

Acute intermittent porphyria (AIP) is a genetic metabolic disorder characterized by neurovisceral attacks. Although high-carbohydrate diets or intravenous glucose administration can help alleviate incipient attacks in patients, these interventions may also promote insulin resistance and increase metabolic risk. This study explored targeted dietary interventions to manage hyperinsulinemia and to enhance glucose uptake in insuli...