Purpose Chronic non-communicable inflammatory skin disorders involve persistent immune activation, oxidative stress, and impaired repair. Conventional topical agents such as corticosteroids often cause adverse effects with long-term use. Epigallocatechin-3-gallate (EGCG), a potent antioxidant and anti-inflammatory polyphenol, shows therapeutic potential but is limited by poor stability and permeability. Hydroxypropyl methylcel...