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Exploring the fatigue phenomenon in individuals with Parkinson’s disease: an Italian multicenter cross-sectional studyNARA Subscribed
Background Fatigue is a common and disabling non-motor symptom in Parkinson’s disease (PD), significantly affecting patients’ quality of life. However, it is often underdiagnosed due to its subjective nature and the lack of a clear definition, hindering the development of effective treatments. Objectives This study aims to investigate the prevalence of fatigue and its associations with sociodemographic factors, disease severit...
The increased ultraviolet radiation (UV) due to the altered stratospheric ozone leads to multiple plant physiological and biochemical adaptations, likely affecting their interaction with other organisms, such as pests and pathogens. Arbuscular mycorrhizal fungi (AMF) and UV-B treatment can be used as eco-friendly techniques to protect crops from pests by activating plant mechanisms of resistance. In this study, we investigated...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Head-down tilt bed rest with or without artificial gravity is not associated with motor unit remodelingNARA Subscribed
Purpose The objective of this study was to assess whether artificial gravity attenuates any long-duration head-down 6 0 bed rest (HDBR)-induced alterations in motor unit (MU) properties. Methods Twenty-four healthy participants (16 men; 8 women; 26–54 years) underwent 60-day HDBR with ( n = 16) or without ( n = 8) 30 min artificial gravity daily induced by whole-body centrifugation. Compound muscle action potential (CMAP), MU...
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